Voluntary exercise regionally augments rates of cerebral protein synthesis
نویسندگان
چکیده
منابع مشابه
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
OBJECTIVE Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance per...
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Exercise increases metabolic rate and the production of reactive oxygen species (ROS) but also elevates protein turnover. ROS cause damage to macromolecules (e.g., proteins) and thereby contribute to aging. Protein turnover removes and replaces damaged proteins. The balance between these two responses may underlie beneficial effects of physical activity on aging. Effects of lifelong exercise on...
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These studies determined whether increases in rates of protein synthesis observed in skeletal muscle after moderate or severe acute-resistance exercise were blunted by insulinopenia. Rats (n = 6-9 per group) were made insulin deficient by partial pancreatectomy or remained nondiabetic. Groups either remained sedentary or performed acute-resistance exercise 16 h before rates of protein synthesis...
متن کاملEffects of thiopental anesthesia on local rates of cerebral protein synthesis in rats.
We have examined the effects of a surgical level of thiopental anesthesia in adult male rats on local rates of cerebral protein synthesis with the quantitative autoradiographicl-[1-14C]leucine method. The relative contribution of leucine derived from protein breakdown to the intracellular precursor amino acid pool for protein synthesis was found to be statistically significantly decreased in th...
متن کاملEffects of thiopental anesthesia on local rates of cerebral protein synthesis in rats
Smith, C. Beebe, C. Eintrei, J. Kang, and Y. Sun. Effects of thiopental anesthesia on local rates of cerebral protein synthesis in rats. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E852–E859, 1998.—We have examined the effects of a surgical level of thiopental anesthesia in adult male rats on local rates of cerebral protein synthesis with the quantitative autoradiographic L-[1-14C]leucine meth...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2013
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2013.09.001